Life Cycle of Toxoplasma gondii.
Toxoplasma gondii was first discovered in a north African rat, the gondi
in the early part of the 20th century. During the early 20th century,
the biology of Toxoplasma was ill-understood with mid-20th century texts
including it with either the fungal groups or protozoa depending on the author.
With the advent of effective electron microscopy in the 1960s, the apical
complex was visualized, forever placing it within the phylum Apicomplexa of the
Kingdom Protista. It is an intracellular parasite of numerous tissues,
particularly skeletal muscle, intestine and nervous tissue. The cycle
includes an intestinal phase (enteroepithelial) in domestic cats and other
felines and an extraintestinal phase in cats and non-cats. The
extraintestinal phase may occur in a number of non-cat hosts, such as humans,
where the disease toxoplasmosis is evident. Rats and other mammals,
including food animals such as pigs, cattle and sheep are commonly
involved in the extraintestinal phase of the life cycle. Humans become
infected through ingestion of poorly cooked meat and also via sporocyst
ingestion from cat feces. Infected rats may be predated by cats, perpetuating
the life cycle. Oocysts fragment into two sporocysts, each of which
contain 4 sporozoites. Ingested sporocysts, zoitocysts and occasionally
tachyzoites may lead to intestinal infections in cats. The
extraintestinal phase of the life cycle often occurs when zoitocysts containing
bradyzoites are ingested, though ingested tachyzoites or sporocysts may also
lead to infections in non-cats, most notably humans. The above diagram
warns that pregnant women should never be given the job of cleaning the pet
cat's litter box. Should a women who was Toxoplasma-free before her
pregnancy, become infected for the first time during a pregnancy, the chances of
her delivering a congenitally-infected child are very high, about 45% of such
pregnancies. About 3500 children are born each year in the US with
congenital toxoplasmosis. Tachyzoites are the active dividing phase during
acute infections and may enter the brain, heart or skeletal muscles where they
multiply more slowly as bradyzoites. In those tissues, bradyzoite clusters
become encysted and are known as zoitocysts. The cyst formation coincides
with developing immune responses which usually confer permanent immunity in that
host. In immunoincompetent individuals such as AIDS victims, bradyzoites
may emerge from zoitocysts and wreak new havoc. Toxoplasmosis is one of
the most common opportunistic diseases associated with AIDS. Backyard
barbecuers inadequately cooking meat, steak tartare (raw beef) commonly eaten in
France and also by gourmets and intrepid diners here in the US, and butchers
through hand contamination, represent significant human sources of
infection. Cats which are feral or even the pet outdoor cat are prime
sources of infection. Any cat which eats rodents should be considered a
potential source of infection, even though it may only "shed" sporocysts for a
brief period of time after infection.