brain section revealing destruction by  Naegleria  trophozoites.The tiny pale blue cells in the evacuolated areas are the amoebae.   100x

trophozoites of Naegleria fowleri in brain section with large centric endosome.  This amoeba is a facultative parasite, free-living in the bottom ooze of ponds and lakes, particularly cooling pools of power plants.  Aspiration of the amoebae into the nose, turns them parasitic.  They migrate through the cribiform plate into the brain where they almost always result in a fatal infection.   1000x